These are all pre-clinical and anecdotal findings that are quite prevalent throughout the internet. One other substantial pre-clinical finding on rats is the ability to lower LDL (bad cholesterol), raise good cholesterol (HDL) as well as lowering blood pressure. These are all accessible online on various websites. The pre-clinical studies are often conducted between 4-12 weeks on rats with differing doses for testing. Pre-clinical studies made by researchers have found a strong capability in rats for fat loss and metabolism increases over short periods of time. The next main finding is that of fat loss. Mice have shown to have quite drastic endurance increases. ![]() The compound itself was banned by the WADA and the NCAA due to the apparent advantages it could provide, which could potentially validate the findings or it could be precautionary on their part. The main conclusion drawn by researchers from pre-clinical studies is the endurance benefit observed in mice. Main research uses: The following are anecdotal analysis that have been determined over time by researchers on rats to find other benefits with GW-501516. The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). Furthermore, in rats treated with GW501516, there was increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity. The PPARδ/coactivator complex then in turn regulates the expression of proteins involved in energy expenditure. In studies conducted on rats, the binding of GW501516 to PPARδ recruits the coactivator PGC-1a. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ. How it works: GW501516 is a selective agonist (activator) of the PPARδ receptor. It has been proposed as a potential treatment for obesity and related conditions as the combination has been shown to significantly increase exercise endurance in animal studies. Pre-clinical studies determined that GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue as well as demonstrating capabilities to reverse metabolic abnormalities in obese subjects with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It is often researched together with other sarms and various research products, thus the grouping and association amongst researchers. It is often grouped with sarms when it is discussed and sold on research sites but it would fall under a different category scientifically. ![]() GW501516 (Cardarine) is a compound that acts as a PPARδ modulator. 07, 2023 (GLOBE NEWSWIRE) - Tucson, Arizona.
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